Title:

Electrospun Bio-derived Polysaccharides and Proteins for Wound Healing Applications

Currently, bandages intended for everyday use focus solely on creating a barrier and trapping moisture. The purpose of this study was to make a patch capable of replacing traditional bandages while actively supporting the wound healing process. Dextran methacrylate is often used in hydrogels for cell culture due to its biocompatibility. Additionally, prior research shows that cells benefit from scaffold structures. With these two factors in mind, we fabricated a dextran methacrylate-based patch via electrospinning. The patches were then sterilized by soaking in ethanol and later cultured with human dermal fibroblast cells to observe cell adhesion. Our findings suggest that electrospinning is an effective way of creating bio-derived patches that replicate scaffolds naturally occurring in the wound healing process. These results suggest potential for future studies exploring the addition of other chemical compounds and physical aids to further improve the patch.

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