Title:

Fabrication of Electrospun Salmon-derived Fibrin Patch for Accelerated Wound Healing

Chronic wounds affect millions of patients, which often fail to heal due to insufficient bioactivity in conventional dressings. This study presents a biomimetic electrospun scaffold composed of dextran methacrylate (DexMA) and salmon-derived fibrinogen, functionalized with thrombin to enable in situ fibrin formation and enhance wound healing. Electrospinning conditions were optimized to produce uniform, stable fiber networks. Scanning electron microscopy confirmed that fibrinogen incorporation increased fiber diameter and structural variability. Human dermal fibroblasts cultured on DexMA/fibrinogen scaffolds exhibited improved attachment and spreading compared to DexMA alone, as shown through fluorescence imaging. These findings indicate that the addition of salmon-derived fibrinogen significantly improves the biological performance of DexMA scaffolds. This platform shows promise as an active wound dressing for promoting tissue regeneration. Future work will focus on cytocompatibility, quantitative migration analysis, and in vivo validation.

Name

Comment*

Comments are viewable only by submitter

Captcha*