Title:

Development and Characterization of Hydrogen Sulfide Releasing Frameworks

Hydrogen sulfide, H2S, has been discovered as the third biological gasotransmitter, possesses astounding antioxidant and anti-inflammatory properties and is key in regulating intercellular mechanisms. Metal-organic frameworks (MOF’s) consist of a metallic coordinating centers and “linkers”, which link together these metallic atoms, donning a precise crystalline morphology with high porosity MOF’s consisting of two sulfur atoms, disulfides, within the linkers can interact with L-cysteine, a thiol containing amino acid responsible for H2S production, in the body to produce a source of slow release H2S. MOF’s consisting of disulfide linkers were synthesized and characterized via powder X-ray diffraction (pXRD) and infrared spectroscopy (IR), then underwent analytical assays, such as a methylene blue derived calibration curve for detection of H2S. Furthermore, malignant cancer cells emit an increased amount of L-cysteine in the 1000-fold, the antioxidant properties allow the cells to continue to survive in such an extreme environment. With the versatile tunability and porosity of MOF’s, disulfide linkers could react with this increased L-cysteine to create endogenously formed H2S and possible chemotherapeutic drug delivery properties.

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