Title:

Reelin Controls the Directional Orientation, Apical Localization and Length of Primary Cilia in Principal Neurons in the Cerebral Cortex

Primary cilia are microtubule-based organelles present on nearly all mammalian cells, including neurons. It is well-known that primary cilia modulate embryonic neurodevelopment. Currently little is known about the roles of neuronal primary cilia in postnatal neurodevelopment. Defects in primary cilia cause neurodevelopmental disorders, obesity, and cognitive impairment. Reelin, a glycoprotein secreted by Cajal–Retzius cells, is essential for neuronal migration and cortical lamination. While Reelin’s role in guiding laminar organization is well established, its influence on primary cilia dynamics and centriole positioning during postnatal development remains unclear. In this study we investigated whether Reelin influences cilia length, centriole positioning, and cilia directionality in the mouse cerebral cortex.

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