Title:

Inkjet-Printed Aptamer-Based Electrochemical Biosensor for Selective Detection of Protein Biomarker

This work presents an inkjet-printed aptamer-based biosensor for the selective detection of lysozyme, an important biomarker in various disease diagnosis. The strong affinity between carbon nanotubes (CNTs) and single-stranded DNAs is exploited to immobilize the aptamers onto the working electrode by printing the ink containing the CNT-aptamer dispersion. The inkjet-printing method enables aptamer density control as well as high resolution patternability. Our developed sensor shows a detection limit of 90 ng/mL with high target selectivity against other proteins. This technology has potential applications in developing low-cost point-of-care diagnostic devices for home healthcare.

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