Title:

Absolute Quantitative Method in Mass Spectrometry

It is highly challenging to do quantitative mass spectrometry analysis without special chemical labelling. Currently, introduction of a stable isotope labelling internal standard (SILIS) is the most recommended strategy to correct the non-uniform (and something fluctuating) efficiencies in ionization, transmission and detection. Unfortunately, it requires extra labor/time cost to synthesize SILIS. For newly discovered compounds, since their structures are yet to be elucidated, the choice, synthesis and utilization of an ideal SILIS become a problem. We present a new quantitative mass spectrometry analysis method without SILIS, performed by quantitatively controlling redox reaction of the analyte derivatized with redox mass tag.

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