Title:

Integrating Cryogelsand Fibrin Gels to Create a Scaffold for Bone Regenerative Medicine

The focus of this research project was to create an improved scaffold for bone regeneration that could be used for treatment of patients with craniofacial defects. Cryogels, which are porous and flexible, were used because they are very personalizable to the patients and the cells can be grown to mold to each individual. The cryogel scaffold was created by combing chitosan with acetic acid and water, then freezing and melting to allow ice crystals to create pores. The fibrin gels were made by mixing fibrinogen and thrombin, and then human dermal fibroblasts (HDFs), were added to it to be encapsulated. This mixture was then injected into the cryogel, and the goal was to have the cells spread and grow evenly throughout the scaffold. The structure of the cryogel scaffold allows for personalized bone healing treatment and provides a solution for patients with cleft palates.

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