Title:

Optimization of Methods to Visualize Hydrogen Peroxide at Cellular Membranes

Ferroptosis is a regulated, iron-dependent form of cell death driven by the peroxidation of phospholipids, the building blocks of cellular membranes. A major research goal in the White-Mathieu Lab is to label cellular membranes with pro-fluorescent molecules in an effort to better understand changes at membranes throughout the progression of this cell death pathway. The goal of this research project was to synthesize a chemical probe capable of tagging cellular membranes and optimize the labeling conditions to ensure that the probe can specifically detect hydrogen peroxide in live cells.

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