Title:

Sonigashira Coupled Ligand for Improved Functionalization of Metal-Organic Framework Drug Delivery System

Metal-Organic Frameworks (MOFs) have been investigated as a targeted method of chemotherapy due to their highly crystalline and orderly(?) structures. Taking advantage of the peptide Glutathione (GSH), which is 100-1000 times more concentrated in tumor cells, MOFs can absorb chemotherapeutics into their porous network and release with contact from GSH. As opposed to accessing their pores, this project looks to successfully functionalize a MOF with a chemotherapeutic prodrug along the crystal surface. Using characterization methods such as powder X-Ray Diffraction (pXRD) and elemental analysis, the functionalized MOF will allow for a controlled payload release of a targeted delivery system.

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