Title:

Dynamics of Human Gut Microbiota in Response to Dietary Intervention with Potato Starch after Bariatric Surgery

Bariatric surgery, including Roux-en-Y gastric bypass (RYGB) and laparoscopic sleeve gastrectomy (LSG), typically yields 50% excess weight loss. Bariatric surgery alters the gut microbiome due to changes in the gastrointestinal environment, dietary modifications, and metabolism. Studies show mixed impacts of bariatric surgery on the gut microbiome, some positive, such as increases in alpha diversity, others negative, including a reduction in straight short-chain fatty acids (SCFAs) levels. SCFAs promote gut barrier integrity, glucose homeostasis, and appetite regulation. Prebiotics, such as dietary fiber or resistant starch, are substrates fermented by the gut microbiome to produce SCFAs. Previous studies have successfully demonstrated that a resistant starch supplement can increase intestinal SCFAs in healthy populations.The objective of this study was to assess the impact of a 30-day resistant starch supplement - potato starch - on fecal SCFA concentrations, SCFA producing bacteria abundance, and associations between fecal SCFAs and SCFA producing bacteria, a population that recently underwent bariatric surgery. This study will fill a critical gap evaluating resistant potato starch in a vulnerable population impacted by obesity, which has primarily been studied in healthy populations. It will also shed light on the underlying mechanisms between prebiotics, fecal SCFA, and gut microbiome composition.

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