Title:

Glutathione-Sensitive Nanocarrier Frameworks for the Synergistic Release of Chemotherapeutics

Advancing innovations in nanocarrier framework materials holds promise for revolutionizing cancer treatment through targeted chemotherapy drug release. Cancer remains the second leading cause of death in the United States, resulting in nearly 2 million cases with over half a million deaths annually. Cancer cells are dysregulated, genetically altered cells arising from normal cellular origins, characterized by uncontrolled proliferation leading to tumor formation. While chemotherapy is commonly used as the primary treatment method, it has limitations such as tumor cell chemoresistance, suboptimal cellular uptake, and adverse systemic effects on patient physiology, due to drug interactions with non-target tissues. Extensive research has been dedicated to nanoscale carriers including porous organic polymers. These advancements aim to enhance drug efficacy while reducing side effects. Studies have shown the promising potential of optimizing nanoscale covalent organic frameworks (nCOFs) for drug delivery applications. The structure of these frameworks must have low cytotoxic impact while maintaining a high degree of tumor-specific physiological triggers. The primary concern with chemotherapy is that, while it effectively targets cancer cells, it also damages healthy cells in the process.

Name

Comment*

Comments are viewable only by submitter

Captcha*