Title:

Quantification of Hydroxy Groups on the Surface of Polymer Nanoparticles

Understanding the surface chemistry of particles within a polymer colloid system is crucial for better understanding polymerization processes. A novel method was developed for quantifying hydroxy groups on the surface of polymer nanoparticles. The challenge lay in differentiating surface-region hydroxy groups from those buried within the particle matrix or present in the serum phase. To address this, an aqueous oxidation using silver(II) picolinate was used to selectively convert surface hydroxy groups into ketones without disrupting particle structure. A quantitative NMR approach was envisioned, wherein trimethylsilyl tags were introduced only to non-oxidized hydroxy groups. This approach has shown promising results, allowing for quantification of hydroxy content in the three regions of interest using readily available reagents with minimal sample preparation.

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