Title:
Reliance on the ATR-CHK1-WEE1 pathway due to R-loop accumulation in Merkel Cell Carcinoma
Poster
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Abstract
Merkel Cell Carcinoma (MCC) is a rare, highly aggressive, neuroendocrine skin cancer that can be caused by UV exposure or integration of the Merkel Cell Polyomavirus. The virus positive MCC cells rely on the ATR-CHK1-WEE1 pathway for survival. This pathway aids in cellular recovery after DNA damage is experienced during replication. By inhibiting proteins in this pathway, MCC cells have reduced proliferation and therefore reduced tumorigenesis.
Authors
| First Name |
Last Name |
|
Evelyn
|
Proctor
|
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Submission Details
Conference GRC
Event Graduate Research Conference
Department Biochemistry (GRC)
Group Poster Presentation
Added April 9, 2024, 8:55 a.m.
Updated April 15, 2024, 7:51 a.m.
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