Title:

Investigating the roles of PRMT5-mediated epigenetic regulations of RNA binding proteins and histones in Merkel Cell Carcinoma

Merkel cell carcinoma (MCC) is a rare but aggressive form of skin cancer. Eighty percent of MCC is caused by Merkel cell polyomavirus (MCPyV), as it is integrated into the human genome. Many factors are involved in the development of cancer, such as protein arginine methyltransferase 5 (PRMT5) which plays a significant role in controlling the oncogenic process, and therapy response. Therefore, I aim to investigate the roles of PRMT5-mediated epigenetic modifications of RNA binding proteins (RBPs) and histones using Merkel cells. Increased PRMT5 expression in several types of cancer has been found to be a potential target for treatment. Hence, it will be critical to further understand the physiological functions of PRMT5 in MCC along with combinatorial therapies or dose-limiting in a therapeutic setting which to date is poorly studied.

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